Birmingham 4 Blackburn 1
Birmingham finished second bottom of the table and surrendered their Premier League status despite a superb victory.
David Murphy put the Blues ahead when his pot-shot found its way under Brad Friedel (31), but Morten Gamst Pedersen knocked in the equaliser (49) after Damien Johnson lost possession.
Cameron Jerome scored twice (73,89) and Fabrice Muamba grabbed the fourth (90) but Fulham's win sealed their fate.
Derby 0 Reading 4
Reading crashed out of the Premier League after their victory over basement club Derby proved in vain.
James Harper curled home the opener into the top corner (15) and striker Dave Kitson slid in to double the lead (61) from Leroy Lita's pass.
Kevin Doyle wrapped up the points from close range (69) and Lita got a late fourth (90), but Fulham's win sent the Royals into the Championship.
Portsmouth 0 Fulham 1
Danny Murphy kept Fulham in the Premier League with a second-half winner.
The midfielder headed in Jimmy Bullard's free-kick (76) to put the Cottagers ahead, although Simon Davies had almost given Fulham an early lead when his shot grazed a post.
American goalkeeper Kasey Keller had earlier maintained parity with smart saves in keeping out a Nico Kranjcar piledriver and a Jermain Defoe shot.